Drug Metabolism and Pharmacokinetics (DMPK)

Welcome to the DMPK knowledge hub, your go-to resource for all things related to the absorption, distribution, metabolism and excretion of compounds.

At Scientist.com we have worked with our industry partners to define research pathways and organizational requirements so that we can enhance the way we make connections with the best service providers. Our helpful guided forms and Research Concierge team will assist you during every phase of your project.

• CYP Induction
• CYP Inhibition Assay
• Drug Drug Interactions

• Caco-2 Cell Permeability
• Metabolite Identification and Profiling
• Red Blood Cell (RBC) Partitioning (Blood/Plasma Ratio)

• Metabolite Identification
• Plasma Protein Binding by Ultracentrifugation
• Cytochrome P450s

• Chronic Bile Duct Cannulation (BDC) Study - Dog / Canine
• Mass Balance Study - Monkey / Non-human Primate
• Ocular Distribution Study - Rabbit

• Pharmacokinetic (PK) Screening - Mouse
• Pharmacokinetic (PK) Screening - Rat
• Pharmacokinetic (PK) Screening - Minipig

• Expired Air Study - Rat
• Quantitative Whole Body Autoradiography (QWBA) - Rodent Species (Mouse, Rat)
• In Vivo Radiolabeled Metabolism

Drug metabolism is a critical early stage of the development process and requires a knowledgeable partner. Scientist.com connects thousands of service providers and researchers to accelerate discussion, collaboration and development.

We have also been developing several bespoke features specifically for DMPK. Did you know that we have a specific In Vivo DMPK Request Form? This form helps you communicate the information about your request clearly and easily to multiple suppliers, helping to reduce time intensive back-and-forth discussions and supporting apples-to-apples comparisons.

Does Scientist.com support DMPK Studies?
Yes, Scientist.com supports a wide range of DMPK studies, including in vivo services. Whether you’re looking for a simple oral gavage pharmacokinetic screening or a bile duct cannulation study, we’ve got you covered.

What species are available?
From BALB/c mice to Göttingen mini pigs - our technical experts will help you find a match!

Where can I complete a series of PK screenings?
Utilize the Scientist.com Supplier Intelligence Portal (SIP) to view supplier capabilities and certifications quickly and easily. The SIP is your one-stop information hub for supplier information.

Can I conduct a radiolabeled study?
Yes, review the suppliers’ In Vivo Services Request for Information (RFI) on their profile to see detailed information about the types of DMPK studies they conduct with details like radiolabeled capabilities, species and even procedures.